| Date | Home | Away | Result |
|---|---|---|---|
| 24/09/25 17:45 | PAOK Saloniki | Maccabi Tel Aviv | --- |
| 24/09/25 17:45 | FC Midtjylland | SK Sturm Graz | --- |
| 24/09/25 20:00 | Dinamo Zagreb | Fenerbahce Istanbul | --- |
| 24/09/25 20:00 | Red Star Belgrad | Celtic Glasgow | --- |
| 24/09/25 20:00 | Sporting Braga | Feyenoord Rotterdam | --- |
| 24/09/25 20:00 | Real Betis Sevilla | Nottingham Forest | --- |
| 24/09/25 20:00 | Malmö FF | PFC Ludogorets Razgrad | --- |
| 24/09/25 20:00 | SC Freiburg | FC Basel | --- |
| 24/09/25 20:00 | OGC Nice | AS Roma | --- |
| 25/09/25 17:45 | OSC Lille | Brann Bergen | --- |
| 25/09/25 17:45 | Go Ahead Eagles Deventer | FCSB Bukarest | --- |
| 25/09/25 20:00 | Glasgow Rangers | KRC Genk | --- |
| 25/09/25 20:00 | Ferencvaros Budapest | Viktoria Plzen | --- |
| 25/09/25 20:00 | Young Boys Bern | Panathinaikos Athens | --- |
| 25/09/25 20:00 | Aston Villa | FC Bologna | --- |
| 25/09/25 20:00 | FC Red Bull Salzburg | FC Porto | --- |
| 25/09/25 20:00 | FC Utrecht | Olympique Lyon | --- |
| 25/09/25 20:00 | VfB Stuttgart | Celta Vigo | --- |