| Date | Home | Away | Result |
|---|---|---|---|
| 23/10/25 17:45 | KRC Genk | Real Betis Sevilla | 0-0 |
| 23/10/25 17:45 | FC Red Bull Salzburg | Ferencvaros Budapest | 2-3 |
| 23/10/25 17:45 | Brann Bergen | Glasgow Rangers | 3-0 |
| 23/10/25 17:45 | Sporting Braga | Red Star Belgrad | 2-0 |
| 23/10/25 17:45 | Olympique Lyon | FC Basel | 2-0 |
| 23/10/25 17:45 | Go Ahead Eagles Deventer | Aston Villa | 2-1 |
| 23/10/25 17:45 | FCSB Bukarest | FC Bologna | 1-2 |
| 23/10/25 17:45 | Fenerbahce Istanbul | VfB Stuttgart | 1-0 |
| 23/10/25 20:00 | Feyenoord Rotterdam | Panathinaikos Athens | 3-1 |
| 23/10/25 20:00 | Maccabi Tel Aviv | FC Midtjylland | 0-3 |
| 23/10/25 20:00 | OSC Lille | PAOK Saloniki | 3-4 |
| 23/10/25 20:00 | Celtic Glasgow | SK Sturm Graz | 2-1 |
| 23/10/25 20:00 | Malmö FF | Dinamo Zagreb | 1-1 |
| 23/10/25 20:00 | SC Freiburg | FC Utrecht | 2-0 |
| 23/10/25 20:00 | Nottingham Forest | FC Porto | 2-0 |
| 23/10/25 20:00 | Young Boys Bern | PFC Ludogorets Razgrad | 3-2 |
| 23/10/25 20:00 | AS Roma | Viktoria Plzen | 1-2 |
| 23/10/25 20:00 | Celta Vigo | OGC Nice | 2-1 |