| Date | Home | Away | Result |
|---|---|---|---|
| 16/09/26 17:45 | FC Ararat-Armenia | Sparta Prag | --- |
| 16/09/26 17:45 | Omonia Nicosia | Celta Vigo | --- |
| 16/09/26 20:00 | Bayer 04 Leverkusen | NK Celje | --- |
| 16/09/26 20:00 | AC Milan | Benfica Lisbon | --- |
| 16/09/26 20:00 | Hapoel Beer Sheva | Dinamo Zagreb | --- |
| 16/09/26 20:00 | Olympiakos Piräus | Jagiellonia Bialystok | --- |
| 16/09/26 20:00 | RSC Anderlecht | Olympique Lyon | --- |
| 16/09/26 20:00 | SK Sturm Graz | Stade Rennes | --- |
| 16/09/26 20:00 | AFC Sunderland | AZ Alkmaar | --- |
| 17/09/26 17:45 | OFI Crete | 1899 Hoffenheim | --- |
| 17/09/26 17:45 | Levski Sofia | FC Red Bull Salzburg | --- |
| 17/09/26 20:00 | Besiktas Istanbul | Olympique Marseille | --- |
| 17/09/26 20:00 | Celtic Glasgow | Ferencvaros Budapest | --- |
| 17/09/26 20:00 | Crystal Palace | Lech Poznan | --- |
| 17/09/26 20:00 | Viktoria Plzen | Royale Union Saint-Gilloise | --- |
| 17/09/26 20:00 | Juventus Turin | NEC Nijmwegen | --- |
| 17/09/26 20:00 | Lillestroem SK | SCU Torreense | --- |
| 17/09/26 20:00 | Real Sociedad | AFC Bournemouth | --- |